Folate (as Quatrefolic®)

Folate (as Quatrefolic®) is a Vitamin supplement available in 1 form.

Not all forms of Folate (as Quatrefolic®) are equal. The form you choose determines how much Folate (as Quatrefolic®) actually reaches your tissues, and the difference between the best and worst forms can be substantial. Quatrefolic (5-MTHF glucosamine salt) completely bypasses the MTHFR enzyme — critical for the estimated 40-60% of the population with MTHFR polymorphisms who cannot efficiently convert folic acid. It is the fourth-generation active folate with superior stability and direct cellular utilization compared to older calcium-salt methylfolate forms.

L-5-methyltetrahydrofolate, calcium salt Preferred (Preferred Form) has a bioavailability rating of high (S1 — best tier). Typical dose range: not yet documented in our database.

Quatrefolic (5-MTHF glucosamine salt) is the fourth-generation active folate form, bypassing the MTHFR enzyme entirely. This is critical for the estimated 40-60% of the population with MTHFR polymorphisms who cannot efficiently convert folic acid. Clinical research demonstrates superior bioavailability and cellular uptake compared to folic acid, with consistent elevation of serum and red blood cell folate levels.

Folic acid and 5-MTHF show equivalent bioavailability and plasma folate response in MTHFR wild-type individuals PMID: 14988450

MTHFR C677T homozygotes show 70% reduced capacity to convert folic acid to active 5-MTHF PMID: 24944062

5-MTHF supplementation bypasses MTHFR polymorphism, achieving equivalent folate status regardless of genotype PMID: 38892484

L-5-methyltetrahydrofolate, calcium salt is classified as Preferred Form by FormulaForge — our top recommendation for Folate (as Quatrefolic®). It carries a bioavailability rating of high (S1 — best tier), meaning more of the active compound reaches your tissues per dose unit compared to lower-rated forms.

When choosing a Folate (as Quatrefolic®) supplement, look for the S1 (best absorption) bioavailability tier on the label. Preferred Forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

For L-5-methyltetrahydrofolate, calcium salt, the typical dosing range is not yet documented in our database. Individual dose requirements vary based on health goals, body weight, and existing nutrient intake.

Side Effects: Specific side effect data for these forms is not yet documented in our database. In general, consult your healthcare provider regarding tolerability at higher doses.

These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Folate (as Quatrefolic®):

Folic acid and 5-MTHF show equivalent bioavailability and plasma folate response in MTHFR wild-type individuals PMID: 14988450

MTHFR C677T homozygotes show 70% reduced capacity to convert folic acid to active 5-MTHF PMID: 24944062

5-MTHF supplementation bypasses MTHFR polymorphism, achieving equivalent folate status regardless of genotype PMID: 38892484

Population frequency of MTHFR C677T homozygosity ranges 10-15%, supporting clinical relevance of methylfolate supplementation PMID: 23482308